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Description

METODĂ DE PREPARARE A ACIDULUI 1-CYCLOPROPYL-6-FLURO-1,4-DIHYDRO-8-METHOXY-7-[()/OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINĂ-CARBOXYLIC

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Interest:

Assignment

Publication info:

No.: RO131120

Date: 30.05.2016

Inventor(s):

DERKACH NATALIIA MYKOLAIVNA [UA]

Applicant(s):
DERKACH NATALIIA MYKOLAIVNA [UA]
Classification:
International patent classification (IPC):
C07D471/04
Cooperative patent classification (CPC):
A61K31/4709 (ES); A61P31/04 (EP); C07D471/04 (EP, CN, ES, GB, RU, US); Y02P20/55 (EP, US)
Application info:
No.: RO20150000957
Date: 05.06.2013
Priority number(s):
UAA201305962 13.05.2013 ; WO2013UA00055 05.06.2013
Related patents:
AU2013389353; BR112015023626; CA2912711; CN104507938; DE112013004452; EA024004; EA201491340; EP2998304; ES2597976; GB2530200; PL415082; RU2015139406; RU2641699; SK288415; SK500662015; UA106556; US2016159788; US9556173; WO2014185881
BOPI:
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Description:

Invenţia se referă la o metodă de preparare a unui compus chimic acid 1-ciclopropil-6-fluoro-1,4-dihidro-8-metoxi-7-[(4aS,7aS)-octahidro-6H-pirolo[3,4-b]piridin-6-il]-4-oxo-3-chinolin-carboxilic. Metoda conform invenţiei cuprinde o adiţie a unei amine heterociclice care conţine o grupare de protecţie, la etil 3-oxo-3-(2,4,5-trifluoro-3-metoxifenil)propanoat, urmată de o reacţie cu etil ortoformiat şi o adiţie a unei amine ciclice, urmată de o ciclizare, rezultând produsul final.

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