Patents

Description

PROCEDEU PENTRU OBTINEREA (3-HALOALCHIL-1H-PIRAZOL-1-IL)-ARILSULFONAMIDELOR

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Interest:

Assignment

Publication info:

No.: RO118200

Date: 28.03.2003

Inventor(s):

ZHI BENXIN [US]

NEWAZ MURAD [US]

TALLEY JOHN J [US]

BERTENSHAW STEPHEN [US]

Applicant(s):
GD SEARLE & CO CHICAGO [US]
Classification:
International patent classification (IPC):
C07C49/15; C07C49/163; C07D231/12
Cooperative patent classification (CPC):
A61P29/00 (EP); A61P3/10 (EP); C07D231/12 (EP, KR, US)
Application info:
No.: RO19970002168
Date: 23.05.1996
Priority number(s):
US19950449975 25.05.1995 ; WO1996US07506 23.05.1996
Related patents:
ATE223383; AU5873696; AU708964; BR9609043; CA2222138; CN1174970; CN1190960; CZ292320; CZ368997; DE69623460; DK0828717; EP0828717; ES2182991; JP3996638; JPH11505848; KR100444802; KR19990021966; MX9709065; NO311130; NO975387; NZ308875; PL187410; PL323492; PT828717; RU2169143; RU2251543; US5892053; US5910597; WO9637476
Description:

Inventia se refera la un procedeu pentru obtinerea (3-haloalchil-1H-pirazol-1-il)-arilsulfonamidelor, cu formula generala I:avand activitate antiinflamatoare si hipoglicemica, si consta in formarea, in prima faza, a unei dicetone, in prezenta unei baze, in solvent, si in condensarea, in a doua faza, a dicetonei formate cu o arilhidrazina sau o sare a acesteia, intr-un solvent adecvat, acidulat pana la o valoare a pH-ului de aproape 7, adaugarea acidului precedand adaugarea arilhidrazinei.

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