DERIVATI DE POLIETILENGLICOLSULFONA, PROCEDEU DE PREPARARE A ACESTOR DERIVATI SI CONJUGATE BIOLOGICE CARE II CONTIN

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Publication info:

No.: RO118434

Date: 30.05.2003

Inventor(s):

HARRIS J MILTON [US]

Applicant(s):
SHEARWATER POLYMERS INC [US]
Classification:
International patent classification (IPC):
A61K47/48; C08G59/14; C08G65/32; C08G65/326; C08G65/329; C08G65/334; C08H1/00

Cooperative patent classification (CPC):
A61K47/50 (KR); A61K47/60 (EP, US); C08G65/32 (KR); C08G65/326 (EP, US); C08G65/329 (EP, US); C08G65/334 (EP, US); Y10S530/815 (EP, US); Y10S530/816 (EP, US)
Application info:
No.: RO19960000959
Date: 14.11.1994
Priority number(s):
US19930151481 12.11.1993 ; WO1994US13013 14.11.1994
Related patents:
ATE215577; AU1054895; AU687937; BG100568; BG63399; BR9408048; CA2176203; CN1085689; CN1137280; CZ137596; CZ295640; DE69430317; DK0728155; EE03448; EE9600128; EP0728155; EP1176160; ES2173943; FI117441; FI962004; HK1042312; HU225649; HU9601253; JP3114998; JPH09508926; KR100225746; KR960705869; NO315377; NO961918; NZ276313; PL180149; PL314298; RO121855; RU2176253; SK284527; SK60896; UA58481; US2002150548; US2004037801; US2005209416; US5446090; US5739208; US5900461; US6610281; US6894025; US7214366; WO9513312
Description:

Inventia se refera la derivati de polietilenglicolsulfona activi, cu structura: R-CH2-CH2-/OCH2CH2)n-Y (I) in care Y reprezinta cel putin un fragment de sulfona, activ, selectat din grupul constand din -SO2-CH=CH2, -SO2-CH2-CH2-X, in care X este halogen, precum si derivati de sulfona activi ai acestora, R reprezinta HO-, H3C-O-, CH2=CH-SO2-, X-CH2-CH2-SO2- sau un fragment activat, altul decat CH2=CH2-CH2-X, acesti derivati activi ai polietilenglicolsulfonei fiind izolabili si stabili hidrolitic. Inventia se refera si la un procedeu de preparare a acestor derivati si la conjugate biologic active, care contin acesti derivati, folositi la modificarea moleculelor si suprafetelor.