PROCEDEE REGIOSELECTIVE PENTRU SINTETIZAREA CIS-1-AMINO-2-INDANOLULUI

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Publication info:

No.: RO118425

Date: 30.05.2003

Inventor(s):

VERHOEVEN THOMAS R [US]

ROBERTS F EDWARD [US]

SENANAYAKE CHRIS H [US]

RYAN KENNETH M [US]

Applicant(s):
MERCK & CO INC [US]
Classification:
International patent classification (IPC):
C07C213/02; C07C215/44; C07C5/42; C07C215/42

Cooperative patent classification (CPC):
C07C213/02 (EP, US); C07C2602/08 (EP, US)
Application info:
No.: RO19960001784
Date: 07.03.1995
Priority number(s):
US19940212604 11.03.1994 ; WO1995US02830 07.03.1995
Related patents:
AU1982195; BR9507031; CA2184257; CN1077881; CN1147244; CZ266196; EP0749410; FI963561; JPH09510205; SK115396; TW328072; US5449830; US5489710; WO9524374
Description:

Inventia se refera la procedee regioselective pentru sintetizarea cis-1-amino-indanolului, compus care inhiba proteaza codificata de virusul imunodeficientei umane (HIV) si, in special, inhiba anumiti analogi de oligopeptida. Procedeele conform inventiei se realizeaza pornind fie de la 1,2-indandiol, cu retinerea integritatii stereochimice a legaturii carbon-oxigen in pozitia 2 a 1,2-indandiolului, fie de la 2-halo-1-indanol, cu inversarea stereochimiei atomului de carbon din pozitia 2 a nucleului de indan.