Patents

Description

AMESTECURI DE AMINOACIZI FARMACEUTIC ACTIVI, DIPEPTIDE, SI PROCEDEU PENTRU PREPARAREA DIPEPTIDELOR

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Interest:

Assignment

Publication info:

No.: RO118656

Date: 29.08.2003

Inventor(s):

MATZKE MICHAEL [DE]

MILITZER HANS CHRISTIAN [DE]

MITTENDORF JOACHIM [DE]

KUNISCH FRANZ [DE]

SCHMIDT AXEL [DE]

SCHONFELD WOLFGANG [DE]

ZIEGELBAUER KARL [DE]

Applicant(s):
BAYER AG [DE]
Classification:
International patent classification (IPC):
A61K31/195; A61K31/27; A61K38/05; A61P31/04; A61P31/10; C07C229/48; C07C231/02; C07C237/04; C07K5/00; C07K5/023; C07K5/06
Cooperative patent classification (CPC):
A61K31/195 (EP, US); A61K38/05 (EP, US); A61P31/04 (EP); A61P31/10 (EP); C07C229/48 (EP, US); C07C237/04 (EP, US); C07K5/06 (KR); C07C2601/08 (EP, US); A61K31/195; A61K2300/00; A61K38/05
Application info:
No.: RO19960001451
Date: 16.07.1996
Priority number(s):
DE19951026274 19.07.1995
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AR003465; ATE198469; ATE344274; AU5948896; AU713555; BG100716; BG62134; BR9603124; CA2181308; CN1115145; CN1143496; CO4700525; CU22820; CZ214396; CZ287896; CZ288204; DE19526274; DK0754678; DK1043332; DZ2073; EE03803; EE9600109; EP0754678; EP1043332; ES2154761; ES2275460; GR3035601; HK1005131; HRP960303; HU9601977; IL118869; JP2007056026; JP3891503; JPH09202761; KR100433968; KR970006312; MA23940; MX9602836; NO315926; NO963000; NZ299008; PE9398; PL184861; PL315330; PT1043332; PT754678; RS49520; RU2181123; SA96170491; SG47158; SI0754678; SI1043332; SK281850; SK284733; SK94796; SV1996000062; TNSN96100; TR199600583; TW496737; UA46725; US5935988; YU20050685; YU41796; ZA966111
Description:

Inventia se refera la amestecuri de aminoacizi farmaceutic activi, care cuprind unul sau mai multi alfa-aminoacizi si/sau derivati ai acestora, si unul sau mai multi ciclopentan-beta-aminoacizi si/sau derivati ai acestora. Dipeptidele sunt alcatuite dintr-un alfa-aminoacid si un ciclopentan-beta-aminoacid. In cadrul procedeului pentru prepararea dipeptidelor, reactioneaza un compus cu formula generala II: cu aminoacizi protejati, cu formula III: rezultand compusi cu formula generala IV: in solventi si in prezenta unei baze, si in final, grupa aminoprotectoare (R10) este scindata, si eventual, dipeptidele sunt transformate in sarurile lor. Amestecurile de aminoacizi, conform inventiei, si/sau dipeptidele sunt utilizate pentru tratarea unor boli, mai ales a micozelor.

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