Patents

Description

DERIVAŢI MIMETICI DE GUANIDINĂ CA INHIBITORI AI FACTORULUI XA

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Interest:

Assignment

Publication info:

No.: RO120543

Date: 30.03.2006

Inventor(s):

LAM PATRICK Y [US]

CLARK CHARLES G [US]

DOMINGUEZ CELIA [US]

FEVIG JOHN MATTHEW [US]

HAN QI [US]

LI RENHUA [US]

PINTO DONALD JOSEPH-PHILLIP [US]

PRUITT JAMES RUSSELL [US]

QUAN MIMI LIFEN [US]

Applicant(s):
DU PONT MERCK PHARMA [US]
Classification:
International patent classification (IPC):
A61K31/416; A61K31/42; A61K31/422; A61K31/423; A61K31/437; A61K31/4375; A61K31/4439; A61K31/47; A61K31/4709; A61K31/4725; A61K31/498; A61K31/502; A61K31/517; A61K31/519; A61K31/5377; A61P7/02; A61P9/10; C07D231/14; C07D231/56; C07D261/20; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D413/04; C07D413/14; C07D471/04; C07D487/04; C07D498/04; C07D513/04; C07D521/00
Cooperative patent classification (CPC):
A61P11/00 (EP); A61P13/12 (EP); A61P43/00 (EP); A61P7/00 (EP); A61P7/02 (EP); A61P9/00 (EP); A61P9/10 (EP); C07D231/12 (EP); C07D231/14 (EP); C07D231/56 (EP); C07D233/56 (EP); C07D249/08 (EP); C07D261/20 (EP); C07D401/04 (EP, KR); C07D401/14 (EP); C07D403/04 (EP); C07D413/04 (EP); C07D413/14 (EP)
Application info:
No.: RO19990001317
Date: 18.06.1998
Priority number(s):
US19970878884 19.06.1997 ; WO1998US12680 18.06.1998
Related patents:
AR015391; ATE302198; AU756755; AU7976898; BR9810137; CA2291442; CN100358888; CN1259942; DE69831238; DK0991638; EA003210; EA200000047; EE04153; EE9900583; EP0991638; ES2244064; HK1028606; HRP980333; HU0002686; IL133525; JP2002505686; JP4319255; KR100546522; KR20010014002; LT4705; LT99147; LV12496; MY119820; NO318359; NO995965; NZ502370; PL192941; PL337756; SI20160; SK172899; SK285685; TW544453; UA57780; WO9857951; ZA985247
Description:

Invenţia se referă la derivaţi mimetici de guanidină care sunt inhibitori ai enzimelor de serin protează, cum ar fi tripsina, în special ai factorului Xa, la compoziţii farmaceutice care conţin aceşti compuşi şi la utilizarea acestora drept agenţi anticoagulanţi pentru tratamentul şi prevenirea tulburărilor tromboembolice. Compuşii conform invenţiei corespund formulei generale (I): în care inelele D şi E reprezintă derivaţi mimetici de guanidină.

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