Patents

Description

INHIBITORI TRICICLICI DE POLI(ADP-RIBOZA) POLIMERAZĂ

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Interest:

Assignment

Publication info:

No.: RO121778

Date: 30.04.2008

Inventor(s):

WEBBER STEPHEN EVAN [US]

CANAN-KOCH STACIE S [US]

TIKHE JAYASHREE GIRISH [US]

THORESEN LARS HENRIK [US]

Applicant(s):
AGOURON PHARMA [US]
CANCER RES CAMPAIGN TECH [GB]
Classification:
International patent classification (IPC):
A61K31/437; A61K31/4375; A61K31/55; A61K31/551; A61P25/28; A61P29/00; A61P3/10; A61P35/00; A61P43/00; A61P9/10; C07D209/00; C07D221/00; C07D223/00; C07D243/00; C07D471/06; C07D487/00; C07D487/06; C07D519/00; A61K; A61P; C07D
Cooperative patent classification (CPC):
A61K31/277 (EP, KR, US); A61K31/4375 (EP, KR, US); A61P25/00 (EP); A61P25/28 (EP); A61P29/00 (EP); A61P3/00 (EP); A61P3/10 (EP); A61P35/00 (EP); A61P43/00 (EP); A61P9/00 (EP); A61P9/10 (EP); C07D471/06 (EP, KR, US); C07D487/06 (EP, KR, US)
Application info:
No.: RO20010000795
Date: 10.01.2000
Priority number(s):
US19990115431P 11.01.1999 ; WO2000US00411 10.01.2000
Related patents:
AP1538; ATE261963; AU2408800; AU781711; BG105811; BG65210; BR0008614; BRPI0008614; CA2360003; CN100418967; CN1342161; CZ20012443; CZ302941; DE60009033; DK1140936; EA004989; EA200100764; EE05006; EE200100364; EP1140936; ES2218110; GEP20033055; HK1040992; HRP20010573; HU0105414; HU229875; ID30138; IL144112; IS5995; JP2002534523; JP4093448; KR100632079; KR20020008112; LT2001083; LT4936; LV12770; MXPA01007001; NO20013313; NO320343; NZ512731; OA11749; OA12185; PL210415; PL357049; PT1140936; RS50031; SI20691; SK287338; SK9662001; TR200102005; UA75034; US2003078254; US2005085460; US2006009517; US6495541; US6977298; US7429578; WO0042040; YU49001; ZA200105399
Description:

Prezenta invenţie se referă la compu?i cu formula (I). Compu?ii cu formula (I) sunt inhibitori ai poli-(ADP-ribozil)transferazei (PARP) ?i sunt utilizaţi ca terapeutice în tratamentul cancerului ?i în ameliorarea congestiei cerebrale, a traumatismelor craniene ?i a bolilor neurodegenerative. Drept terapeutice pentru cancer, compu?ii conform invenţiei pot fi utilizaţi, de exemplu, încombinaţie cu agenţi citostatici ?i/sau cu radiaţii.

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